bioRxivBioinformaticsPreprint
What is hidden in the darkness? Characterization of AlphaFold structural space.
Abstract
The recent public release of the latest version of the AlphaFold database has given us access to over 200 million predicted protein structures. We use a "shape-mer" approach, a structural fragmentation method analogous to sequence k-mers, to describe these structures and look for novelties - both in terms of proteins with rare or novel structural composition and possible functional annotation of under-studied proteins. Data and code will be made available at https://github.com/TurtleTools/afdb-shapemer-darkness
- assay: protein structure
- research focus: protein structure prediction
- research focus: benchmarking
- approach: deep learning
- approach: statistical model
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