bioRxivEvolutionary BiologyPreprint
Convergent evolution of mevalonate pathway in Inonotus obliquus and Betula pendula.
O. Safronov, G. Lutfullahoglubal, N. Sipari, M. Wilkens, P. Safdari, O.-P. Smolander, J. Lihavainen, N. Silvan, S. Rajaraman, P. K. Laine, L. Paulin, P. Auvinen, T. Sarjala, K. Overmyer, J. Kangasjarvi, B. Battersby, U. Richter, J. Salojarvi
Abstract
Inonotus obliquus, Chaga mushroom, is a fungal species from Hymenochaetaceae family (Basidiomycota) which has been widely used for traditional medicine in Europe and Asia. Here, chaga genome was sequenced using Pacbio sequencing into a 50.7Mbp assembly consisting of 301 primary contigs with an N50 value of 375 kbp. Genome evolution analyses revealed a lineage-specific whole genome duplication event and an expansion of Cytochrome P450 superfamily. Fungal biosynthetic clusters were enriched for tandemly duplicated genes, suggesting that biosynthetic pathway evolution has proceeded through small-scale duplications. Metabolomic fingerprinting confirmed a highly complex terpene biosynthesis chemistry when compared against related fungal species lacking the genome duplication event.
- organism: fungi (other)
- assay: whole-genome sequencing
- research focus: chromatin & epigenetic regulation
- approach: experimental assay
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