Y. Yin

Restoring O-glycosylation and expression of MUC2 limits progression of colorectal cancer

This study shows that restoring MUC2 O-glycosylation and expression via rosiglitazone inhibits colorectal cancer progression by enhancing intestinal barrier function.

Regulation of angiogenesis by endocytic trafficking mediated by cytoplasmic dynein 1 light intermediate chain 1

This study shows that LIC1 and RILPL1/2 restrict angiogenesis by promoting VEGFR2 degradation, and their disruption increases angiogenesis through enhanced Rab11-mediated recycling.

Armored Bicistronic CAR T Cells with Dominant-negative TGF-β Receptor II to Overcome Resistance in Glioblastoma.

This paper develops a tri-modular CAR T cell construct with a dominant-negative TGF-β receptor II to overcome GBM resistance by enhancing T cell function and efficacy in a preclinical model.

In vivo affinity maturation of the HIV-1 Env-binding domain of CD4

This study demonstrates that non-antibody protein biologics can undergo affinity maturation in vivo, leading to improved binding affinity and neutralization potency against HIV-1.

In vitro antimicrobial mechanism of diacerein and potential to reverse MRSE resistance to β-lactams

This study investigates diacerein's antimicrobial mechanism against MRSE and shows it can reverse β-lactam resistance by affecting efflux systems and inducing cell lysis.

Structure basis for recognition of 26RFa by the pyroglutamylated RFamide peptide receptor

This study determines the cryo-EM structure of QRFPR bound to 26RFa, revealing the recognition mechanism and aiding drug design for obesity and diabetes.

pH selects for distinct N2O-reducing microbiomes in tropical soil microcosms

This study investigates N2O reduction in acidic tropical soils, finding distinct microbial communities and novel taxa associated with N2O reduction at low pH.

Temporal genomic analysis of melanoma rejection identifies regulators of tumor immune evasion

The paper identifies Mif as a regulator of tumor immune evasion in low intra-tumor heterogeneity melanoma by analyzing single-cell RNA sequencing data and validating in patient data.

In vivo affinity maturation of murine B cells reprogrammed to express human antibodies

This study demonstrates that CRISPR-edited murine B cells expressing human antibodies can undergo affinity maturation, generating potent neutralizing antibodies against HIV-1 and SARS-CoV-2.

Interfacial water confers transcription factors with dinucleotide specificity

The paper investigates how transcription factors recognize DNA dinucleotides through structural analysis, revealing water-mediated mechanisms that enhance specificity beyond mononucleotide recognition.

Permanent Neonatal diabetes-causing Insulin mutations have dominant negative effects on beta cell identity

This study investigates two INS mutations causing permanent neonatal diabetes, showing they impair beta cell function through misfolded proinsulin, ER stress, and dedifferentiation.

Intermittent fasting promotes type 3 innate lymphoid cells secreting IL-22 contributing to the beigeing of white adipose tissue

This study shows intermittent fasting increases IL-22 production by intestinal ILC3s, promoting beigeing of white adipose tissue and improving metabolic health.

Probing the DCAF12 interactions with MAGEA3 and CCT5 C-terminal degrons

This study characterizes DCAF12 interactions with MAGEA3 and CCT5 degrons using biophysical assays and cryo-EM, revealing key residues for degron recognition and informing PROTAC design.

Single cell spatial analysis and biomarker discovery in Hodgkin lymphoma

This study uses spatial imaging to analyze Hodgkin lymphoma tumor microenvironments and identifies new biomarkers related to immune cell interactions and checkpoints.

The spatially resolved tumor microenvironment predicts treatment outcome in relapsed/refractory Hodgkin lymphoma

The paper develops a prognostic model using spatially resolved tumor microenvironment features to predict treatment outcomes in relapsed/refractory Hodgkin lymphoma.

Colocalization of Protein and microRNA Markers Reveals Unique Extracellular Vesicle Sub-Populations for Early Cancer Detection

This study introduces NOBEL-SPA to analyze EV sub-populations by colocalizing protein and miRNA markers, identifying unique signatures for early breast cancer detection.

Broadly effective ACE2 decoy proteins protect mice from lethal SARS-CoV-2 infection

This paper develops two ACE2 decoy proteins that neutralize diverse SARS-CoV-2 variants and protect mice from lethal infection with high survival rates.

Heavy-chain CDR3-engineered B cells facilitate in vivo evaluation of HIV-1 vaccine candidates

The paper evaluates HIV-1 vaccine candidates using HCDR3-engineered B cells, finding that SOSIP-TM mRNA-lipid nanoparticles induce stronger anti-apex responses than multimerized SOSIP proteins.

Brassinosteroid gene regulatory networks at cellular resolution

The paper identifies BR-responsive gene expression in Arabidopsis root cells using single-cell RNA-sequencing and reveals HAT7 and GTL1 as transcription factors regulating cell elongation.

The gut microbiota promotes liver regeneration through hepatic membrane phospholipid synthesis

This study shows that gut microbiota supports liver regeneration by promoting hepatic phospholipid synthesis, with antibiotic-induced dysbiosis impairing this process.

Latent human herpesvirus 6 is reactivated in chimeric antigen receptor T cells

The paper identifies HHV-6 reactivation in CAR T cells using single-cell sequencing and links it to clinical neurotoxicity observed in patients.

Pathway and mechanism of tubulin folding mediated by TRiC/CCT conjugated with its ATPase cycle revealed by cryo-EM

This study reveals the pathway and mechanism of TRiC-mediated tubulin folding using cryo-EM structures and XL-MS, showing how tubulin is stabilized during the ATPase cycle.

Structural basis of plp2-mediated cytoskeletal protein folding by TRiC/CCT

This study uses cryo-EM to reveal structural details of TRiC/CCT-mediated folding of tubulin and actin with plp2, showing how plp2 coordinates substrate translocation and folding.

A Caenorhabditis elegans nck-1 and filamentous actin-regulating protein pathway mediates a key cellular defense against bacterial pore-forming proteins

This paper identifies a novel C. elegans pathway involving nck-1 and the actin cytoskeleton that mediates defense against bacterial pore-forming proteins, independent of MAPK signaling.

Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball patterned arrays

This study develops Stereo-seq, a high-resolution spatial transcriptomic method, to analyze mouse organogenesis and map developmental disease loci.

Functional testing of PI3K inhibitors stratifies responders to idelalisib and identifies treatment vulnerabilities in idelalisib-refractory/intolerant chronic lymphocytic leukemia

This study uses ex vivo drug sensitivity testing to identify treatment responses and vulnerabilities in chronic lymphocytic leukemia patients, showing that pan-PI3Ki and combinations with venetoclax can be effective in idelalisib-refractory/intolerant cases.

A potent synthetic nanobody with broad-spectrum activity neutralizes SARS-Cov-2 virus and Omicron variant through a unique binding mode

This paper reports a synthetic nanobody, C5G2, that neutralizes SARS-CoV-2 and Omicron variants with high potency through a unique binding mechanism.

Novel Antibody Interfaces Revealed Through Structural Mining

This study identifies novel antibody interfaces through structural analysis, revealing recurrent motifs and enabling their functional validation and optimization.

Integration of multi-omics data reveals interplay between brassinosteroid and TORC signaling in Arabidopsis

The paper integrates multi-omics data to uncover molecular interactions between BR and TORC signaling in Arabidopsis, revealing shared regulatory mechanisms in growth and stress responses.

Brassinosteroids modulate autophagy through phosphorylation of RAPTOR1B by the GSK3-like kinase BIN2 in Arabidopsis

This study shows that brassinosteroids modulate autophagy in Arabidopsis by phosphorylating RAPTOR1B via BIN2 kinase, linking BR signaling to TOR-mediated autophagy regulation.