Foot placement coordination is impaired in people with Parkinson's Disease

Abstract

BackgroundGait instability is a common and disabling symptom of Parkinsons disease (PD), contributing to frequent falls and reduced quality of life. While clinical balance tests and spatiotemporal gait measures can predict fall risk, they do not fully explain the underlying control mechanisms. In healthy individuals, foot placement is actively adjusted based on an internal estimate of the center of mass state to maintain gait stability, known as foot placement control. This estimation relies on the integration of multisensory information, which has been shown to be impaired in PD, potentially disrupting the control of gait stability through foot placement. ObjectiveTo investigate whether foot placement coordination during overground walking is impaired in people with PD. MethodsFifty people with PD and 51 healthy older adults walked overground for ten minutes at self-selected, comfortable walking speed. Foot placement errors were quantified as the deviation between the actual foot placement and the predicted placement derived from the center of mass kinematic state during the preceding swing phase. ResultsFoot placement errors were significantly higher in people with PD than in healthy older adults in both mediolateral (p < .05) and anteroposterior directions (p < .0001), at both mid-swing and terminal swing. Relative explained variance in mediolateral direction was significantly higher in people with PD compared to healthy older adults (p < .005). ConclusionWe provide first evidence of impaired coordination between the center of mass and foot placement in PD. Future work should investigate a causal relationship between impaired foot placement control, sensorimotor integration and gait instability.