Approximation of bone mineral density and subcutaneous adiposity using T1-weighted images of the human head

Abstract

Bones and brain are intricately connected and scientific interest in their interaction is growing. This has become particularly evident in the framework of clinical applications for various medical conditions, such as obesity and osteoporosis. The adverse effects of obesity on brain health have long been recognised, but few brain imaging studies provide sophisticated body composition measures. Here we propose to extract the following bone- and adiposity-related measures from T1-weighted MR images of the head: an approximation of skull bone mineral density (BMD), skull bone thickness, and two approximations of subcutaneous fat (i.e., the intensity and thickness of soft non-brain head tissue). The measures pertaining to skull BMD, skull bone thickness, and intensi-ty-based adiposity proxy proved to be reliable (r=.93/.83/.74, p<.001) and valid, with high correlations to DXA-de-rived head BMD values (rho=.70, p<.001) and MRI-derived abdominal subcutaneous adipose volume (rho=.62, p<.001). Thickness-based adiposity proxy had only a low retest reliability (r=.58, p<.001).The outcomes of this study constitute an important step towards extracting relevant non-brain features from available brain scans.