Tobias Kaufmann

Inter- and intra-individual trajectories of brain sex in different neuroendocrine profiles

The paper uses machine learning to analyze brain sex classification from MRI data and links brain sex fluctuations to neuroendocrine profiles in individuals with different hormonal states.

Decomposing response inhibition: a POMDP model

The paper introduces a POMDP model to analyze inhibitory control in the Stop Signal Task, identifying computational attributes linked to ADHD scores in a large cohort.

Sex-stratified insights into the genetics of brain volumes in late adulthood

This study examines the genetic architecture of brain volumes in males and females, finding similar patterns but sex-dependent gene-level variability in limbic regions.

Thalamic Nuclei Volumes Across Psychiatric and Neurological Disorders: A Multi-Site Magnetic Resonance Imaging Study

This study compares thalamic nucleus volumes across multiple psychiatric and neurological disorders using MRI, finding significant volume reductions in specific regions associated with different conditions.

Whole-brain drug distribution profiles of psychedelic drugs provide insights into rapid antidepressant action

The paper develops anatomical distribution profiles of psychedelic and anaesthetic drugs to understand their rapid antidepressant effects by combining pharmacodynamic data with receptor density maps.

Brain anatomy in major hormonal transition phases: Longitudinal and cross-sectional volume associations with menarche and menopause

The paper examines brain volume changes associated with menarche and menopause using MRI data, finding overlapping but opposing effects in specific brain regions across both phases.

Traces of parenthood but not pregnancy loss in UK Biobank structural brain MRI data

The paper examines structural brain MRI data from UK Biobank to determine if neuroanatomical changes reflect parenthood or pregnancy loss, finding that parenthood, not pregnancy loss, is associated with volumetric differences.

Predicting Developmental Norms from Baseline Cortical Thickness in Longitudinal Studies

This paper develops and compares Baseline-Conditioned Norms (B-Norms) and Cross-Sectional Norms (C-Norms) for predicting longitudinal cortical thickness changes, finding B-Norms provide better fits and detect pubertal changes more effectively.

Optimizing automated sleep stage scoring of 5-second mini-epochs: a transfer learning study

This paper optimizes an existing deep learning model for 5-second sleep stage scoring, achieving performance comparable to human and 30-second automated scoring, and demonstrating increased capture of sleep transitions.

An Evolutionary Perspective on the Genetics of Anorexia Nervosa

This study identifies genetic overlaps between anorexia nervosa, BMI, and age at menarche, suggesting evolutionary factors may underlie the development of AN.

Genetic overlap between multivariate measures of human functional brain connectivity and psychiatric disorders

This study identifies genetic overlap between functional brain connectivity and six psychiatric disorders using multivariate genome-wide association analysis in 30,701 UK Biobank individuals.

Interrelated effects of age and parenthood on whole-brain controllability: protective effects of parenthood in mothers

This study examines how age and parenthood affect whole-brain controllability, finding that parenthood preserves controllability in mothers but not in men.

Unveiling the Genetic Landscape of Basal Ganglia: Implications for Common Brain Disorders

This study identifies 72 genetic loci associated with basal ganglia volumes and finds significant genetic overlaps with Parkinson's disease, schizophrenia, and migraine.

The Genetic Architecture of Amygdala Nuclei

This study identifies genetic loci associated with amygdala nuclei volumes using UK Biobank data, finding both unique and shared genetic architectures and immune-related pathways.

Genetic architecture of brain age and its casual relations with brain and mental disorders

The paper estimates brain age gap (BAG) using neural networks and identifies eight genomic regions associated with BAG, finding causal relationships with Alzheimer's and bipolar disorder but not Parkinson's, depression, or schizophrenia.

Abundant pleiotropy across neuroimaging modalities identified through a multivariate genome-wide association study

The paper identifies abundant genetic pleiotropy across neuroimaging modalities using a multivariate genome-wide association study in two cohorts.

Estimating bone marrow adiposity from head MRI and identifying its genetic architecture

The paper estimates bone marrow adiposity from head MRI scans and identifies its genetic architecture, revealing heritability, 41 genetic loci, and correlations with cognitive ability and Parkinson's disease.

Shared genetic architecture between mental health and the brain functional connectome in the UK Biobank

The paper identifies shared genetic variants between self-reported mental health and brain functional connectivity in the UK Biobank using multivariate statistical methods.

Distributed genetic architecture across the hippocampal formation implies common neuropathology across major brain disorders

The paper identifies 173 genetic loci associated with hippocampal formation volume and finds genetic overlap with eight brain disorders.

Mind the gap: performance metric evaluation in brain-age prediction

This study evaluates performance metrics in brain-age prediction across datasets, showing variability based on age range, sample size, and age-bias correction.

The role of liver fat in cardiometabolic diseases is highlighted by genome-wide association study of MRI-derived measures of body composition

This study conducts a GWAS on MRI-derived body composition measures, identifying genetic loci and genes associated with body composition and cardiometabolic diseases, with liver fat showing strong genetic associations.

The genetic architecture of human cortical folding

This study identifies 856 genetic loci associated with sulcal depth through a genome-wide association study using UK Biobank data, showing higher heritability and locus yield compared to cortical thickness and surface area.

Multivariate genome-wide association study identifies 780 unique genetic loci associated with cortical morphology.

The paper uses a multivariate GWAS approach to identify 780 genetic loci associated with cortical morphology, showing a 10-fold increase in loci compared to univariate methods.

Genetic overlap between Alzheimer's disease and depression mapped onto the brain

This study identifies genetic overlap between Alzheimer's disease and depression using GWAS data and biostatistical tools, finding shared variants and brain morphology associations.

Population-based body-brain mapping links brain morphology and body composition

This study links brain morphology and body composition using MRI data from 19,330 UK Biobank participants, finding significant associations between body measures and brain structures.

Genome-wide association analysis of the human thalamus identifies novel genomic loci and reveals genetic overlap with distinct cortical regions and ten brain disorders

This study identifies 42 genetic loci associated with thalamus and its nuclei volumes and finds genetic overlaps with cortical regions and ten brain disorders.

Fast qualitY conTrol meThod foR derIved diffUsion Metrics (YTTRIUM) in big data analysis: UK Biobank 18608 example

The paper introduces YTTRIUM, a QC method for diffusion MRI data, showing it improves brain age prediction accuracy in UK Biobank data.

Association between complement component 4A expression, cognitive performance and brain imaging measures in UK Biobank

The paper investigates the association between predicted brain C4A expression and cognitive performance and brain imaging measures in the UK Biobank, finding significant negative associations and structural mediation effects.

A history of previous childbirths is linked to women's white matter brain age in midlife and older age

The paper links the number of previous childbirths to white matter brain age in midlife and older women using UK Biobank data.

Functional brain network modeling in sub-acute stroke patients and healthy controls during rest and continuous attentive tracking

The paper analyzes functional brain networks in sub-acute stroke patients and healthy controls during rest and attentive tracking, finding task-dependent connectivity changes but no group classification differences.