SARS2Mutant: SARS-CoV-2 Amino-Acid Mutation Atlas Database

Abstract

The coronavirus disease 19 (COVID-19) is a highly pathogenic viral infection of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), resulting in the global pandemic of 2020.A lack of therapeutic and preventive approaches including drugs and vaccines, has quickly posed significant threats to world health. A comprehensive understanding of the evolution and natural selection of SARS-CoV-2 against the host interaction and symptoms at the phenotype level could impact the candidates strategies for the fight against this virus. SARS-CoV-2 Mutation (SARS2Mutant, http://sars2mutant.com/) is a database thatprovides comprehensive analysis results based on tens of thousands of high-coverage and high-quality SARS-CoV-2 complete protein sequences. The structure of this database is designed to allow the users to search for the three different strategies among amino acid substitution mutations based on gene name, geographical zone or comparative analysis. Based on each strategy, five data types are available to the user: mutated sample frequencies, heat map of the mutated amino acid positions, timeline trend for mutation survivals and natural selections, and charts of changed amino acids and their frequencies. Due to the increase of virus protein sequence samples published daily showing the latest trends of current results, all sequences in the database are reanalyzed and updated monthly. The SARS-2Mutant database providescurrent analysis and updated data of mutation patterns and conserved regions, helpful in developing and designing targeted vaccines, primers and drug discoveries.