Frontiers in Cellular and Infection MicrobiologyMolecular BiologyPeer-reviewed journal article
GDF15 and ACE2 stratify COVID19 patients according to severity while ACE2 mutations increase infection susceptibility.
Margalida Torrens‐MasiD, Catalina M. Perelló-Reus, Neus Trias-Ferrer, Lesly Ibargüen-GonzáleziD, Catalina Crespı́iD, Aina Maria Galmes-PanadesiD, Cayetano Navas-EnamoradoiD, Andrés Sánchez-PoloiD, Javier Pierola Lopetegui, Lluís MasmiqueliD, Lorenzo Socías Crespí, Carles BarcelóiD, Marta González‐FreireiD
Abstract
Coronavirus disease 19 (COVID-19) is a persistent global pandemic with a very heterogeneous disease presentation ranging from a mild disease to dismal prognosis. Early detection of sensitivity and severity of COVID-19 is essential for the development of new treatments. In the present study, we measured the levels of circulating growth differentiation factor 15 (GDF15) and angiotensin-converting enzyme 2 (ACE2) in plasma of severity-stratified COVID-19 patients and healthy control patients and characterized the in vitro effects and cohort frequency of ACE2 SNPs. Our results show that while circulating GDF15 and ACE2 stratify COVID-19 patients according to disease severity, ACE2 missense SNPs constitute a risk factor linked to infection susceptibility.
- organism: human
- assay: protein sequence
- research focus: differential expression
- approach: statistical model
- Citations
- 9
- FWCI
- 0.85
- Field percentile
- top 27%
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