Author

M. Calcagnile

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

M. Alifano· 2 shared P. Alifano· 2 shared P. Forgez· 2 shared A. Iannelli· 1 shared C. Bucci· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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2 shared papersMicrobiology

M. Alifano

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2 papers

Recent·Most cited

The lethal triad: SARS-CoV-2 Spike, ACE2 and TMPRSS2. Mutations in host and pathogen may affect the course of pandemic.

M. Calcagnile, P. Forgez, P. Alifano, M. Alifano

This study uses in silico methods to show how mutations in SARS-CoV-2 Spike protein affect interactions with ACE2 and TMPRSS2, and how host genetic variation influences these interactions.

bioRxiv · Jan 12, 2021 · PreprintMicrobiology

ACE2 polymorphisms and individual susceptibility to SARS-CoV-2 infection: insights from an in silico study

M. Calcagnile, P. Forgez, A. Iannelli, C. Bucci, M. Alifano, P. Alifano

This study uses in silico analysis to show that ACE2 SNPs S19P and K26R may affect SARS-CoV-2 spike binding, with S19P potentially offering protection and K26R possibly increasing disease severity.

bioRxiv · Apr 23, 2020 · PreprintMicrobiology