Cell SystemsBioinformaticsPeer-reviewed journal article
Multiscale Co-expression in the Brain
Benjamin D. HarrisiD, Megan CrowiD, Stephan FischeriD, Jesse A GillisiD
Abstract
Single-cell RNA-sequencing (scRNAseq) data can reveal co-regulatory relationships between genes that may be hidden in bulk RNAseq due to cell type confounding. Using the primary motor cortex data from the Brain Initiative Cell Census Network (BICCN), we study cell type specific co-expression across 500,000 cells. Surprisingly, we find that the same gene-gene relationships that differentiate cell types are evident at finer and broader scales, suggesting a consistent multiscale regulatory landscape.
- organism: mouse
- assay: scRNA-seq
- research focus: differential expression
- research focus: gene regulatory network inference
- approach: statistical model
- Citations
- 38
- FWCI
- 1.57
- Field percentile
- top 16%
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