Genozip 14 - advances in compression of BAM and CRAM files

Abstract

SummaryGenozip performs compression of a wide range of genomic data, including widely used FASTQ, BAM and VCF file formats. Here, we introduce the latest advancement in Genozip technology, focused on compression of BAM and CRAM files. We demonstrate Genozips ability to compress data generated by a variety of study types (e.g., whole genome sequencing, DNA methylation, RNASeq), sequencing technologies and aligners, up to 2.7 times better than the current state of the art compressor, CRAM version 3.1. Availability and implementationGenozip is freely available for academic research use and has been tested for Linux, Mac and Windows. Installation instructions are available at https://genozip.com/installing.html. A user manual is available at https://genozip.com/manual.html. Supplementary informationSupplementary data are available.