bioRxivCancer BiologyPreprint
Is evolutionary conservation a useful predictor for cancer long noncoding RNAs? Insights from the Cancer lncRNA Census 3
A. Vancura, A. H. Gutierrez, T. Hennig, C. Pulido-Quetglas, F. Slack, R. Johnson, S. Haefliger
Abstract
Evolutionary conservation is a measure of gene functionality that is widely used to prioritise long noncoding RNAs (lncRNA) in cancer research. Intriguingly, while updating our Cancer LncRNA Census, we observed an inverse relationship between year of discovery and evolutionary conservation. This observation is specific to cancer over other diseases, implying a sampling bias in selection of lncRNA candidates and casting doubt on the value of evolutionary metrics for prioritisation of cancer-related lncRNAs.
- organism: human
- assay: long-read sequencing
- research focus: gene regulatory network inference
- research focus: differential expression
- research focus: clustering
- research focus: cell type annotation
- approach: statistical model
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