Jenny Chen

Cellular evolution of the hypothalamic preoptic area of behaviorally divergent deer mice

The paper builds a cellular atlas of the hypothalamic preoptic area in two deer mouse species, identifying cell types linked to behavioral differences and sex-specific evolution.

A quantitative model for characterizing the evolutionary history of mammalian gene expression

The paper uses an OU process to model gene expression evolution across mammals and identifies expression pathways under different selection pressures.

Genetic analysis of isoform usage in the human anti-viral response reveals influenza-specific regulation of ERAP2 transcripts under balancing selection

The paper identifies genetic variants influencing isoform usage in the anti-viral response, revealing ERAP2's role in balancing selection and influenza-specific regulation.

Reconstruction of developmental landscapes by optimal-transport analysis of single-cell gene expression sheds light on cellular reprogramming.

Optimal transport converts a 65,781-cell reprogramming time course into probabilistic fates and trajectories, exposing alternative cell fates and a gene, Obox6, that improves reprogramming efficiency.

Evolutionary analysis across mammals reveals distinct classes of long noncoding RNAs

The paper introduces a computational tool for lncRNA discovery and analysis, identifying two distinct classes of lncRNAs based on evolutionary patterns.