T. Hennig

Building Blocks of Understanding: Constructing a Reverse Genetics Platform for studying determinants of SARS-CoV-2 replication.

This paper develops a reverse genetics platform for SARS-CoV-2 to generate recombinant viruses and study their replication and phenotypic effects.

Decoding murine cytomegalovirus

This paper reannotates MCMV gene expression using multi-omics data, identifying hundreds of novel transcripts and ORFs, including small ORFs that regulate gene expression and a new immediate-early transcript.

Is evolutionary conservation a useful predictor for cancer long noncoding RNAs? Insights from the Cancer lncRNA Census 3

The paper examines the relationship between evolutionary conservation and the discovery year of cancer lncRNAs, finding an inverse correlation that suggests potential sampling bias and questions the utility of evolutionary metrics in prioritizing cancer lncRNAs.

Data-Driven Design of Protein-Derived Peptide Multiplexes for Biomimetic Detection of Exhaled Breath VOC Profiles

The paper designs peptide-based sensors using machine learning and OBPs to detect VOCs in exhaled breath for disease monitoring.

The Epstein-Barr virus ubiquitin deconjugase BPLF1 regulates the activity of Topoisomerase II during virus replication

This study identifies BPLF1 as a regulator of TOP2 activity during EBV replication by modulating ubiquitination, SUMOylation, and DNA-damage response.

pUL36 de-ubiquitinase activity augments both the initiation and progression of lytic virus infection in IFN-primed cells

This study shows that pUL36 DUB activity helps HSV-1 overcome IFN resistance and enhance lytic infection in IFN-primed cells.

Concatemeric Broccoli reduces mRNA stability, aggregates and induces p-body formation

This study investigates the effects of Broccoli-aptamer concatemers on mRNA stability, aggregation, and p-body formation in different cellular contexts.

Dissecting HSV-1-induced host shut-off at RNA level

This study quantifies HSV-1-induced host shut-off mechanisms and identifies gene-specific transcriptional changes during early infection.

Integrative functional genomics decodes herpes simplex virus 1

This study decodes the complete HSV-1 transcriptome and translatome during lytic infection, identifying novel transcripts, ORFs, and regulatory elements.

P-TEFb activation by RBM7 shapes a pro-survival transcriptional response to genotoxic stress

This study shows RBM7 activates P-TEFb to promote cell survival during genotoxic stress by enhancing Pol II elongation and transcription of DDR genes.