Catecholamine Precursor Modulation of Human Exploration:Evidence From a Large Gender-Balanced Sample

Abstract

The catecholamine precursor tyrosine has been linked to improved cognitive performance, but investigations into decision-making and reinforcement learning processes known to be under catecholamine control are sparse. We examined the impact of a single dose of Tyrosine (2g) on reinforcement learning and exploration in a large (n=63) gender-balanced sample in a within-subjects preregistered study. Reinforcement learning performance was improved under Tyrosine, and computational modeling revealed that this performance increase was due to a stabilization of choice behavior reflected in increased value-driven exploitation. Further non-preregistered modeling analyses confirmed that accounting for higher-order perseveration substantially improved model fit, and substantiated the observation of increased value-driven exploitation under Tyrosine. Furthermore, it revealed a more fine-grained computational impact of Tyrosine, showing attenuated effects of directed exploration and value-independent perseveration. Supplementation with Tyrosine therefore improved reinforcement learning performance by stabilizing choice patterns in the service of optimizing reward accumulation. Results confirm that Tyrosine supplementation modulates specific computational mechanisms thought to be under catecholamine control.