Noncoding RNAs endogenously rule the cancerous regulatory realm while proteins govern the normal

All cancers share a commonality in genome activation regulated by a systems endogenous network distinct from normal tissue, but such a network remains elusive. Here, we unearth a systems regulatory network endogenous for all types of cancers and normal human respectively from massive data, including all RNAseq data available from SRA and TCGA, and reveal distinctive systems realm for cancer and normal. In the cancerous realm, noncoding RNAs, especially pseudogenes, dominate endogenous network modules and centrality, and they work as the strongest systems inducers that cis-regulate their targets. However in the normal realm proteins dominate the entire endogenous network centrally controlled by ribosomal proteins and they trans-regulate their targets. Our finding establishes a systems picture of an endogenous mechanism overlooking the cancerous and normal realm, in which noncoding RNAs rule the overall cancer realm while proteins govern the normal one. This fundamentally refreshes the conventional concept of cancerous mechanism.