PREDICTING EVOLUTIONARY TRANSITIONS IN TOOTH COMPLEXITY WITH A MORPHOGENETIC MODEL

Abstract

The extent to which evolutionary transitions are shaped by developmental bias remains poorly understood. Classically, morphological variation is assumed to be abundant and continuous, but if morphogenesis biases how traits vary than evolutionary transitions might follow somewhat predictable steps. Compared to other anatomical structures, teeth have an exceptional fossil record which documents striking evolutionary trajectories toward complexity. Using computer simulations of tooth morphogenesis, we examined how varying developmental parameters influenced transitions from morphologically simple to complex teeth. We find that as tooth complexity increases, development tends to generate progressively more discontinuous variation which could make the fine-tuning of dietary adaptation difficult. Transitions from simple to complex teeth required an early shift from mesiodistal to lateral cusp patterning which is congruent with patterns of dental complexification in early mammals. We infer that the contributions of primary enamel knot cells to secondary enamel knots which are responsible for patterning lateral cusps may have been an important developmental innovation in tribosphenic mammals. Our results provide evidence that development can bias evolutionary transitions and highlights how morphogenetic modelling can play an important role in building more realistic models of morphological character evolution.