Author

K. E. Sears

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 6

Signature Assays, Organisms & Methods

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Research Focus:development & morphogenesis· 4 Organism:mouse· 4 Approach:statistical model· 3 Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2 Approach:experimental assay· 2 Assay:imaging· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

A. A. Sadier· 2 shared A. Haghani· 2 shared J. A. Zoller· 2 shared K. Raj· 2 shared S. Horvath· 2 shared S. Santana· 2 shared A. Couzens· 1 shared A. Krause· 1 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersEvolutionary Biology

A. A. Sadier

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6 papers

Recent·Most cited

On the cusp of adaptive change: the hierarchical radiation of phyllostomid bats

D. M. Grossnickle, A. A. Sadier, E. Patterson, N. N. Cortes-Viruet, S. Jimenez Rivera, K. E. Sears, S. Santana

This study examines the hierarchical diversification pattern in phyllostomid bats using molar morphology, finding an initial rapid burst followed by slower diversification within adaptive zones.

bioRxiv · May 23, 2023 · PreprintEvolutionary Biology

Bat teeth illuminate the diversification of mammalian tooth classes

A. Sadier, N. Anthwal, A. Krause, R. Dessalles, M. Lake, L. Bentolila, R. Haase, N. Nieves, S. Santana, K. E. Sears

The paper studies how tooth classes in bats evolved and diversified by analyzing developmental mechanisms and growth rate modulation.

bioRxiv · Dec 5, 2021Evolutionary Biology

Epigenetic clock and methylation studies in gray short-tailed opossums

S. Horvath, A. Haghani, J. A. Zoller, K. Raj, I. Sinha, A. Talbot, Y. Aviles Ruiz, K. E. Sears

The paper generates DNA methylation data from opossum tissues and develops epigenetic clocks for opossums and dual-species human-opossum clocks to measure age.

bioRxiv · Oct 13, 2021 · PreprintEvolutionary Biology

Ecological constraints on highly evolvable olfactory receptor genes and morphology

L. R. Yohe, M. Fabbri, D. Lee, K. Davies, T. P. Yohe, M. K. Sanchez, E. Rengifo, R. Hall, G. Mutumi, B. P. Hedrick, A. A. Sadier, N. B. Simmons, K. E. Sears, E. Dumont, S. Rossiter, , L. Davalos

The paper examines how ecological factors influence the evolution of olfactory receptor genes and morphology in bats, finding that increased reliance on olfaction correlates with reduced genetic diversity in these genes.

bioRxiv · Sep 6, 2021 · PreprintEvolutionary Biology

DNA Methylation Networks Underlying Mammalian Traits

A. Haghani, A. T. Lu, C. Z. Li, T. R. Robeck, K. Belov, C. E. Breeze, R. T. Brooke, S. Clarke, C. G. Faulkes, Z. Fei, S. H. Ferguson, C. J. Finno, V. N. Gladyshev, V. Gorbunova, R. G. Goya, , S. Horvath

This study analyzes DNA methylation across 11,117 samples from 176 species to identify modules related to traits like age, lifespan, and phylogeny, revealing epigenetic patterns across evolution and aging.

bioRxiv · Mar 16, 2021Evolutionary Biology

PREDICTING EVOLUTIONARY TRANSITIONS IN TOOTH COMPLEXITY WITH A MORPHOGENETIC MODEL

A. Couzens, K. E. Sears, M. Rücklin

This study uses a morphogenetic model to show that developmental bias can shape predictable evolutionary transitions in tooth complexity by influencing variation patterns during morphogenesis.

bioRxiv · Nov 7, 2019 · PreprintEvolutionary Biology