OmicsPharLeuDB: an integrative database for mining pharmacogenomic data in acute lymphoblastic leukemia

Abstract

Leukemia is one of the most common hematological malignancies in children. Recent cancer pharmacogenomic studies profiled large panels of cell lines against hundreds of approved drugs and experimental chemical compounds. However, until now, no comprehensive databases have been specifically designed for leukemia. Therefore, we have developed OmicsPharLeuDB (mugpeng.shinyapps.io/leu_web_english_peng_v2/), a database that includes the largest published studies investigating the viability response of human leukemia cell lines to chemical compound treatment, and the association between drug sensitivity and multi-omics, and also provides a user-friendly interactive website allowing the user to assess drug sensitivity data from a different platform and find the potential relationship between drugs and omics.