Targeting Fe3O4 Au nanoparticles in photoacoustic nuclear magnetic dual-mode imaging

Abstract

Multi-mode complementary imaging can improve the accuracy of medical diagnosis. Multi-mode probes are a bridge between various imaging modes, which means that the development of multi-mode, multi-functional nano-probes is very necessary. This paper develops a targeted as a probe for nuclear magnetic and photoacoustic dual-mode imaging, Fe3O4@Au nanoparticles have superparamagnetism and can enhance the nuclear magnetic signal of T2 sequence. The needle has optical absorption properties and can enhance photoacoustic signals. After modifying the surface of Integrin monoclonal antibody, the probe has selective targeting to U87-MG tumor cells. Nuclear magnetic based on Fe3O4@Au nanoparticles /Photoacoustic dual-mode imaging will play a major role in tumor diagnosis.