R. Zhang

Integrated Transcriptomic and Translatomic Profiling Reveals Noncanonical RNA Junctions and Hidden Coding Potential in Porcine Epidemic Diarrhea Virus

This study identifies noncanonical RNA junctions and hidden coding potential in PEDV using integrated transcriptomic and translatomic approaches.

Genome-wide screen identifies novel factors for surface protein cross-wall trafficking and cell envelope homeostasis in Staphylococcus aureus

This study identifies novel factors regulating YSIRK protein cross-wall trafficking and cell envelope homeostasis in S. aureus through a transposon mutant screen and phenotypic analysis.

Transcriptome-wide identification of 5-methylcytosine by deaminase and reader protein-assisted sequencing

This paper introduces DRAM, a method for transcriptome-wide m5C detection using deaminase and reader proteins, showing high overlap with BS-seq data and supporting low-input RNA.

The HLA-E/NKG2A axis identifies a therapeutic vulnerability in BCG-unresponsive bladder cancer

This study identifies the HLA-E/NKG2A axis as a therapeutic target in BCG-unresponsive bladder cancer by showing its role in immune evasion and impaired effector cell function.

Targeting LxCxE cleft pocket of retinoblastoma protein in M2 macrophages inhibits ovarian cancer progression

This study shows targeting the LxCxE cleft pocket of Rb in M2 macrophages inhibits ovarian cancer progression by reducing immunosuppressive TAMs and enhancing T cell infiltration.

Multiplexed transcriptomic analyses of the plant embryonic hourglass

The paper uses spatial transcriptomics to compare gene expression patterns in plant embryos, revealing a phylotypic hourglass pattern similar to animals, indicating an ancient conserved mechanism for morphological development.

Engineering probiotic Escherichia coli Nissle 1917 to block transfer of multiple antibiotic resistance genes by exploiting a type I CRISPR-Cas system

This paper engineers Escherichia coli Nissle 1917 to block antibiotic resistance gene transfer using a type I CRISPR-Cas system, showing efficacy in vitro and in zebrafish.

Directed Evolution of Acoustic Reporter Genes Using High-Throughput Acoustic Screening

The paper evolves acoustic reporter genes using high-throughput acoustic screening to enhance nonlinear ultrasound scattering.

Loss of an extensive ciliary connectome induces proteostasis and cell fate switching in a severe motile ciliopathy

The paper identifies cellular defects beyond motility loss in ciliopathies caused by CCDC39/CCDC40 variants, showing proteostasis disruption and cell fate switching.

Lack of dominant-negative activity for tumor-associated ZNRF3 missense mutations at endogenous expression levels

This study shows that tumor-associated ZNRF3 missense mutations do not exhibit dominant-negative activity and instead act as loss-of-function mutations at endogenous levels.

Spatial integration of sensory input and motor output in Pseudomonas aeruginosa chemotaxis through colocalized distribution

This study shows that chemoreceptor clusters and flagellar motors colocalize at the same pole in Pseudomonas aeruginosa, controlled by FlhF, and that CheY overexpression increases c-di-GMP, causing cell aggregation.

Dilated cardiomyopathy-associated skeletal muscle actin (ACTA1) mutation R256H disrupts actin structure and function and causes cardiomyocyte hypocontractility

This study shows that the ACTA1 R256H mutation disrupts actin structure and function in cardiomyocytes, leading to reduced contractility and a likely causative role in dilated cardiomyopathy.

Spatiotemporal regulation of Pseudorabies Virus Thymidine kinase UL23 by post-translational modification

This study investigates SUMO modification of PRV UL23 and shows it affects subcellular localization but not stability.

A Real-time Multi-Subject Three Dimensional Pose Tracking System for Analyzing Social Behaviors of Non-human Primates

This paper introduces MarmoPose, a real-time 3D pose tracking system for non-human primates, enabling analysis of social behaviors and closed-loop experiments in marmosets.

Unraveling the Role of Urea Hydrolysis in Salt Stress Response during Seed Germination and Seedling Growth in Arabidopsis thaliana

This study shows that salt stress increases urea hydrolysis in Arabidopsis thaliana, raising cytoplasmic pH and inhibiting seed germination and seedling growth, challenging the traditional view of ammonium toxicity as the main cause.

PathEX: Make Good Choice for Whole Slide Image Extraction

PathEX improves tile image extraction from whole slide images by adjusting IoT and BoT parameters to focus on annotated regions' boundaries and exclude blank tiles.

YAP promotes chromosomal instability by transcriptionally activating AJUBA through its super enhancer in breast cancer

This study identifies YAP's role in promoting chromosomal instability in breast cancer by activating AJUBA through its super enhancer, leading to AURKA activation and aberrant mitosis.

Accumulation of Oncogenic Mutations During Progression from Healthy Tissue to Cancer

The paper models mutation accumulation during cancer progression, analyzing premalignant population sizes and waiting times to malignancy in colorectal cancer and chronic myeloid leukemia.

Synthetic integrin antibodies discovered by yeast display reveal αV subunit pairing preferences with β subunits

The paper discovers synthetic antibodies specific to RGD-binding integrins and identifies their subunit pairing preferences.

A multi-institutional study to investigate the sparing effect after whole brain electron FLASH in mice: Reproducibility and temporal evolution of functional, electrophysiological, and neurogenic endpoints

This study evaluates the reproducibility and temporal evolution of FLASH and CONV irradiation effects on mice, showing FLASH sparing at late but not early time points.

Integrative Omics Uncovers Low Tumorous Magnesium Content as A Driver Factor of Colorectal Cancer

This study identifies low tumorous magnesium content as a driver factor of colorectal cancer by showing its impact on gene mutations, EMT activation, and cell migration through DBN1 phosphorylation.

Rim4 is a Meiotic Thermal Sensor and Drives Biogenesis of Stress Granules

This paper identifies Rim4 as a meiotic thermal sensor that forms reversible condensates triggered by heat, promoting stress granule assembly and protecting meiotic processes from thermal stress.

Morphological deficits of glial cells in a transgenic mouse model for developmental stuttering

The paper examines glial cell morphology in a Gnptab-mutant mouse model linked to stuttering, finding altered astrocyte and microglia processes in vocal production circuits.

Profiling cellular heterogeneity and fructose transporter expression in the rat nephron by integrating single-cell and microdissected tubule segment transcriptomes

The paper integrates single-cell and microdissected transcriptomes to show fructose transporter expression varies across rat nephron segments, with S3 being the primary site of fructose reabsorption.

Effects of greening-induced warming and cooling on tree phenology in temperate and boreal forests

This study shows forest greening alters tree phenology by causing earlier spring and autumn events through seasonal biophysical warming and cooling effects.

Androgen deprivation triggers a cytokine signaling switch to induce immune suppression and prostate cancer recurrence

Molecular Regulation of Invasive Protrusion Formation at the Mammalian Fusogenic Synapse

The paper identifies the spatiotemporal coordination of WAVE and N-WASP with actin-bundling proteins in invasive protrusion formation at the mammalian fusogenic synapse.

Successful spread of mcr-1-bearing IncX4 plasmids is associated with variant in replication protein of IncX4 plasmids

The paper shows that IncX4 plasmids with pir-1 have higher mcr-1 expression and fitness burden but lower invasion rates compared to pir-2 plasmids, explaining why mcr-1 is absent from pir-2 plasmids.

Tagging of water masses with covariance of trace metals and prokaryotic taxa in the Southern Ocean

The paper examines links between prokaryotic taxa and trace metals in Southern Ocean water masses using PLSR analysis.

Virus specificity and nucleoporin requirements for MX2 activity are affected by GTPase function and capsid-CypA interactions

This study shows that MX2 antiviral activity depends on CypA-CA interactions and GTPase function, with loss of GTPase activity altering Nup requirements for viral restriction.