Dynamic effects of fructose and Momordica charantia supplementation on pulmonary hypertension in broiler chickens

Abstract

This study evaluated the effects of short-term, low-dose supplementation with high-fructose corn syrup (HFS) and Momordica charantia (Mo) on pulmonary arterial hypertension (PAH) and system dynamics in hypertensive broiler chickens. Thirty male Cobb broilers were divided into three groups (n=10): HFS, Mo, and control. PAH was surgically induced at day 17, and supplementation was provided from days 20 to 37. Measurements included body weight, feed intake, heart indices, and tissue composition. A dynamic model (Yaantal fe Bro A1) using differential equations was developed and showed strong correlations with observed data (0.90 < r < 1.0). HFS increased feed intake and weight gain; Mo enhanced feed efficiency and selective tissue growth. Both supplements reduced PAH severity, with HFS being more effective. These findings support the application of system dynamics modeling in evaluating nutritional strategies for obesity-related hypertension in avian models.