Daniel P. Kelly

The paper identifies shared and distinct genetic architectures for cardiac structure and function using UK Biobank data, revealing common variants influencing multiple chambers and phenotypic variability.

This study identifies heterogeneous mTORC1 activity and a novel ERK-dependent pathway driving 4EBP1 phosphorylation in cardiomyocytes during hypertrophy, revealing dual translational control mechanisms.

This study shows ketone body oxidation is essential for neuronal function and survival, particularly in neurodegenerative diseases like Alzheimer's.

This paper shows that deleting MondoA globally protects against diet-induced obesity by increasing energy expenditure through enhanced glucose uptake and glycolytic flux, leading to elevated glycerol synthesis and lipolysis.

This paper develops a two-hit mouse model of HFpEF combining diet-induced obesity and renin-mediated hypertension, showing key features of the disease and response to therapy.

This study shows that SGLT2 inhibitors improve heart failure in mice independently of their metabolic effects, even when SGLT2 is absent.

The paper identifies a mitofusin 2 mutation (R400Q) that causes mitophagic cardiomyopathy by impairing mitochondrial fusion and Parkin recruitment, distinct from its role in CMT2A.