C. M. Magin

Dynamically stiffening biomaterials reveal age- and sex-specific differences in pulmonary arterial adventitial fibroblast activation

This study uses dynamic biomaterials to show age and sex differences in hPAAF activation in response to stiffness, linking findings to the estrogen paradox in PAH.

Tissue-engineered models of lung cancer premalignancy

This paper develops a tissue-engineered model of human lung cancer premalignancy using hydrogel-embedded lung slices exposed to cigarette smoke carcinogens, showing the formation of premalignant lesions and testing chemoprevention agents.

3D-bioprinted, phototunable hydrogel models for studying adventitial fibroblast activation in pulmonary arterial hypertension

This paper develops a 3D-bioprinted hydrogel model to study fibroblast activation in pulmonary arterial hypertension, showing increased fibrotic and proliferative markers in stiffer matrices.

Chemical modification of human decellularized extracellular matrix for incorporation into phototunable hybrid-hydrogel models of tissue fibrosis

This paper develops a phototunable hybrid-hydrogel system using chemically modified human decellularized extracellular matrix to study fibrosis-related mechanosensing and cell-matrix interactions.

Transitional alveolar epithelial cells and microenvironmental stiffness synergistically drive fibroblast activation in three-dimensional hydrogel lung models

This paper develops a 3D hydrogel model of lung tissue to study fibroblast activation in IPF, showing that transitional epithelial cells and microenvironmental stiffness synergistically drive myofibroblast activation.

Disulfide disruption reverses mucus dysfunction in allergic airway disease

This study shows that reducing disulfide bonds in mucins reverses mucus dysfunction in asthma by improving mucociliary clearance and reducing airway hyperreactivity.