bioRxivPharmacology & ToxicologyPreprint
Evaluating the efficacy of LUMPY-NIL herbal powder, dermal Spray and dermal ointment in treating Lumpy Skin Disease (LSD) in Bovines
Abstract
BackgroundLumpy Skin Disease (LSD) lacks targeted treatment options and is managed using antibiotics and anti-inflammatory drugs. This study evaluated the efficacy of a polyherbal combination therapy in the management of LSD in affected bovines. Materials and Methods52 dairy cattle clinically diagnosed with LSD were enrolled in a field trial conducted under veterinary supervision. All animals received LUMPY-NIL Herbal Powder orally at 30 g twice daily, along with topical application of LUMPY-NIL Dermal Spray on closed nodules and LUMPY-NIL Ointment on open wounds. Daily monitoring included clinical signs, lesion progression, systemic symptoms, and milk yield recovery. ResultsTreatment duration varied from 7 to 21 days depending on severity of the disease. New lesion formation ceased within 2-4 days of treatment initiation. Systemic symptoms such as fever, lethargy, and inappetence resolved within 1-3 days. Open wounds showed progressive healing with no signs of infection, and nodules dried and sloughed off by day 15 in most animals. Milk yield showed partial recovery (20%) by day 7 and returned to baseline by day 15. The reduction in nodule size and number ranged from 81% to 94% by days 10-15. No adverse effects were observed during the treatment period. ConclusionThe polyherbal treatment combining demonstrated promising therapeutic benefits in managing clinical symptoms and accelerating recovery in LSD-infected cattle.
- assay: clinical cohort / trial
- research focus: host-pathogen & immune response
- approach: experimental assay
- Citations
- 1
Reproducibility ledger
Nobody has reported trying to reproduce this paper yet. Did you replicate an experiment or run the code? Your report saves the next lab a week.
Sign in to file a reproducibility report.
Related papers
- Evaluation of the safety, immunogenicity and efficacy of a new live-attenuated lumpy skin disease vaccine in India
N. Kumar, S. Barua, … B. N. Tripathi·bioRxiv·Dec 10, 2022
- The immune response to lumpy skin disease virus in cattle is influenced by inoculation route
P. C. Fay, N. Wijesiriwardana, … P. Beard·bioRxiv·Sep 22, 2022
- To cull or not to cull: a model-based evaluation of response strategies against Lumpy Skin Disease outbreaks
Thibaut Jombart, Jessica L. Abbate·bioRxiv·Jan 2, 2026
- Isolation and characterization of lumpy skin disease virus from cattle in India
N. Kumar, Y. Chander, … B. N. Tripathi·bioRxiv·Oct 8, 2020
- Primary bovine white blood cells support dissemination of Lumpy Skin Disease Virus while suppressing viral replication
Manoj Kumar, Ohad Frid, … Sharon Karniely·Veterinary ResearchPeer-reviewed·Apr 26, 2025
- Retention of Lumpy Skin Disease Virus in Stomoxys Spp (Stomoxys Calsitrans, Stomoxys Sitiens, Stomoxys Indica) following intrathoracic inoculation, Diptera: Muscidae.
A. Issimov, L. Kutumbetov, … P. J. White·bioRxiv·Aug 13, 2020