Disrupted stemness and redox homeostasis in mesenchymal stem cells of neonates from mothers with obesity: implications for increased adiposity

Abstract

Maternal obesity is a risk factor for increased fetal adiposity. The underlying mechanisms remain unclear, however, emerging evidence suggests that mesenchymal stem cells (MSCs), which are the precursors of adipocytes, from neonates of mothers with obesity exhibit enhanced adipogenic differentiation potential. We hypothesise that the MSCs of neonates from mothers with obesity have different stemness potential and redox state compared to the MSCs from mothers with normal weight. MSCs were isolated from neonates of women with obesity (BMI>30 kg/m{superscript 2}, OB-MSCs) and women with normal weight (BMI View larger version (23K): org.highwire.dtl.DTLVardef@1638346org.highwire.dtl.DTLVardef@3f9caaorg.highwire.dtl.DTLVardef@46925eorg.highwire.dtl.DTLVardef@1336dfa_HPS_FORMAT_FIGEXP M_FIG C_FIG