Maternal Obesity Reprograms Differentiation Trajectories of Fetal Hematopoietic Stem and Progenitor Cells Through Altered Inflammatory Signaling
Brianna M. Doratt, Hamed Hemati, Sheridan B. Wagner…·Ilhem Messaoudi
This study shows maternal obesity disrupts fetal bone marrow hematopoiesis by altering HSPC maturation, reprogramming lineage trajectories, and inducing inflammatory bias in a nonhuman primate model.