Effect of KNL1 on the proliferation and apoptosis of colorectal cancer cells

Abstract

BackgroundTo identify the expression of KNL1 in colorectal tumor tissues and to clarify the function of this gene on the proliferation capability of colorectal cancer cells.\n\nMethodsThirty-six pairs of colorectal tumor and normal tissue were collected and subjected to quantitative PCR analysis. KNL1 was under-expressed using lentiviral transfection, and the function of KNL1 was evaluated by proliferation assay, colony formation and apoptosis assay.\n\nResultsKNL1 was highly expressed in colorectal tumor tissues. KNL1 downregulation inhibited colorectal cancer cell proliferation and promoted apoptosis.\n\nConclusionsKNL1 plays an effective role in decreasing the apoptosis and promoting the proliferation of colorectal cancer cells.