A platform for robust quantitative functional genomics reveals temporal fitness landscapes in African trypanosomes
Simon D’Archivio, Lorenzo Brusini, Sandra Trindade, Luísa M. Figueiredo, Catarina Gadelha, Bill Wickstead
DRiF-Seq, a sequencing-optimized RNAi platform with a posteriori noise estimation, quantifies clone-resolved fitness genome-wide in pleomorphic Trypanosoma brucei; over half of core genes carry fitness costs.
bioRxiv · Jul 23, 2026 · PreprintCell Biology✦ In-depth digest