Early Prenatal Cell-Free DNA Methylation Landscape Informs Epigenetic Purification of the Circulating Fetal Genome
Tiepeng Liao, Chinmay Rao, Siya Iyer, Spencer C Ding, Jingru Yu, Zackary Lui, Cindy Yang, Wei Gu
The paper develops an epigenetic enrichment method for fetal cfDNA using a first-trimester methylome reference, increasing fetal fraction from 5.1% to 28.4%.
bioRxiv · Oct 25, 2026 · PreprintGenomics