Genetically proxied inhibition of angiotensinogen synthesis is associated with lower cardiovascular risk
Panagiotis Zangas, Murad Omarov, Lanyue Zhang, Marios K. Georgakis
AGT variants mimicking hepatic angiotensinogen synthesis inhibition are linked, via drug-target Mendelian randomization, to lower coronary artery disease, stroke and heart failure risk and higher potassium.
medRxiv · Mar 9, 2026 · PreprintGenetic & Genomic Medicine✦ In-depth digest