Renin-Angiotensin System Studies

A physiology-based mathematical model of the renin-angiotensin system, bone remodeling, and calcium homeostasis: Effects of estrogen and renin-angiotensin system inhibitors

The paper develops a mathematical model to study how estrogen decline and RAS inhibitors affect bone remodeling and calcium homeostasis in post-menopausal women.

Structural and functional significance of arginine at position 2 of angiotensin II: Implications for oxidant-mediated amino acid residue conversions

The paper investigates the role of arginine at position 2 of angiotensin II and shows that its conversion to glutamic acid or proline via oxidant-mediated mechanisms alters cellular signaling responses.

Angiotensin II–Driven Coronary Vasculopathy and Pressure-Overload Myocardial Remodeling Represent Distinct Vascular Phenotypes

This study compares hemodynamic and neurohumoral stress in cardiac remodeling, showing that AngII promotes vascular changes while TAC causes myocardial fibrosis.

Naturally occurring ACE2 stalk variants are differentially released from the cell.

The paper identifies naturally occurring ACE2 stalk variants that differentially affect soluble ACE2 release and surface expression of B0AT1.

The renin angiotensin system in cognitive flexibility: Effects of single-dose losartan on task-switching in healthy volunteers

This study investigates the effect of a single dose of losartan on cognitive flexibility in healthy volunteers using a task-switching paradigm, finding no significant improvement in task-switching performance.

Angiotensin II Type 1 Receptor Blockade Inhibits Gastric Cancer Metastasis Through Tight Junction Restoration

This study shows that blocking the angiotensin II type 1 receptor reduces gastric cancer metastasis by restoring tight junctions through mechanisms involving KLF4 and TJ protein expression.

Ovarian Hormones Moderate Hypertension in Female Eln Haploinsufficient Mice

This study investigates how ovarian hormones affect blood pressure differences in female Eln haploinsufficient mice, finding that ovariectomy alters diastolic blood pressure and sodium retention mechanisms.

Protein Phosphatase 2A Subunit B55 Alpha is Required for Angiotensin Type 2 Receptor Elicited Natriuresis

This study shows that PP2A B55 binds to activated AT2R and is essential for AT2R signaling, natriuresis, and intracellular trafficking in renal proximal tubule cells.

Role of adipocyte angiotensinogen or angiotensin type 1a receptors in the development of diet-induced atherosclerosis or angiotensin II-induced abdominal aortic aneurysms

This study investigates the role of adipocyte angiotensinogen or angiotensin type 1a receptors in diet-induced atherosclerosis and AngII-induced abdominal aortic aneurysms, finding minimal effects on disease outcomes but increased adipocyte size in AT1aR-deficient mice.

Acid-Sensing Ion Channel 1a Deficiency Drives Endocrine Hypertension in Male Mice

This study shows that ASIC1a deficiency in male mice causes endocrine hypertension through aldosterone excess and sympathetic overactivity, while female mice are unaffected.

Identification and characterization of alamandine-(1-5), a new component of the Renin-Angiotensin System with unique properties

This study identifies and characterizes alamandine-(1-5), a new RAS component with unique biological activities and increased plasma concentration in nephropathic patients.

Impact of Proximal Tubule-Specific Deletion of Dipeptidyl Peptidase 4 on Blood Pressure, Renal Sodium Handling, and NHE3 Phosphorylation

This study examines the impact of DPP4 deletion in proximal tubules on blood pressure, sodium handling, and NHE3 phosphorylation in mice, finding that DPP4 modulates NHE3 activity and Ang II sensitivity.

Smooth muscle LRRC8A knockout preserves vascular function in AngII hypertension

This study shows that LRRC8A knockout in vascular smooth muscle cells protects against AngII-induced vascular dysfunction and preserves BP dipping in hypertension.

Psychological trauma increases blood pressure sensitivity to angiotensin II via T-lymphocytes independent of psychopathology

This study shows that traumatic stress increases blood pressure sensitivity to angiotensin II via T-lymphocytes, independent of psychopathology, using a mouse model of repeated social defeat stress.

Inhibition of Renin Release, a Crucial Event in Homeostasis, is Mediated by Coordinated Calcium Oscillations within Juxtaglomerular Cell Clusters.

This study investigates how AngII inhibits renin release in JG cell clusters through coordinated calcium oscillations, identifying key cellular mechanisms involved.

Association of ACE I/D Polymorphism with Essential Hypertension in South-Asian Populations, Gender-Bias in Indian Populations: Evidence from Case-Control and Meta-Analysis Studies

The paper investigates the association of ACE I/D polymorphism with essential hypertension in South-Asian populations, finding a significant risk allele and gender bias in Indian populations.

Vasoinhibin is Generated by the Renin-Angiotensin System

This study identifies renin as a protease that cleaves prolactin to generate vasoinhibin, a RAS-mediated regulator of blood vessel growth and function.

Mathematical Modeling of Impacts of Patient Differences on Renin-Angiotensin System and Applications to COVID-19 Lung Fibrosis Outcomes

This paper develops a multiscale computational model to study how patient-specific factors affect the renin-angiotensin system and its role in COVID-19 lung fibrosis outcomes.

Oxidized low-density lipoprotein potentiates angiotensin II-induced Gq activation through the AT1-LOX1 receptor complex: Implications for renal dysfunction

This study shows oxLDL enhances Ang II-induced Gq signaling via the AT1-LOX1 complex, contributing to renal dysfunction in CKD and hypertension.

Mathematical modeling of the influence of ACE I/D polymorphism on blood pressure and antihypertensive therapy

This study uses a computational model to examine how the ACE I/D polymorphism affects blood pressure and antihypertensive therapy efficacy, finding limited predictive value of the variant.

Analysis of the Combined Effect of rs699 and rs5051 on Angiotensinogen Expression and Hypertension

This study investigates the combined effect of rs699 and rs5051 on angiotensinogen expression and hypertension, finding no significant difference in liver AGT expression or hypertension phenotypes when the variants occur independently.

Functional Exploration of Conserved Sequences in the Distal Face of Angiotensinogen

This study investigates the functional role of conserved sequences in the loop and β-sheet regions of angiotensinogen, showing that mutations in either region individually have no effect, but combined mutations impair AGT secretion.

Repeated ethanol exposure and withdrawal alters ACE2 expression in discrete brain regions: Implications for SARS-CoV-2 infection

The paper examines how chronic ethanol exposure affects ACE2 and TMPRSS2 expression in specific brain regions, suggesting increased vulnerability to SARS-CoV-2 neuroinvasion.

Angiotensin II Inhibits the A-type K+ Current of Hypothalamic Paraventricular Nucleus Neurons in Rats with Heart Failure: Role of MAPK-ERK1/2 Signaling

This study investigates how angiotensin II modulates the A-type K+ current in PVN neurons via the MAPK-ERK pathway in rats with heart failure.

Deficiency of MicroRNA-181a Results in Transcriptome-Wide Cell Specific Changes in the Kidney that Lead to Elevated Blood Pressure and Salt Sensitivity

This study shows that miR-181a deficiency in mice leads to elevated blood pressure and salt sensitivity through increased renin expression and widespread renal gene dysregulation.

Renal Angiotensinogen in Nonhuman Primates is Predominantly Liver-Derived

This study shows that renal angiotensinogen in nonhuman primates is mainly derived from the liver, as evidenced by reduced renal AGT levels after liver-specific AGT inhibition.

A primitive type of renin-expressing lymphocyte protects the organism against infections

The paper identifies renin-expressing B-1 lymphocytes that control bacterial infections by releasing renin and phagocytosing bacteria, linking renin's endocrine role to immune defense.

Effects of Renin-Angiotensin Inhibition on ACE2 and TMPRSS2 Expression: Insights into COVID-19

This study investigates whether renin-angiotensin inhibition affects ACE2 and TMPRSS2 expression in mice, finding no changes in ACE2 but a decrease in TMPRSS2 in lungs with AGT depletion.