Pediatric Pain Management Techniques

Differential maturation of the brain networks required for the sensory, emotional and cognitive aspects of pain in human newborns

This study maps the postnatal development of brain networks for pain processing in infants, showing differential maturation of sensory, affective, and cognitive pain subnetworks.

Investigating the effectiveness of cannabidiol to mitigate the adverse consequences of exposure to neonatal procedural pain

This study investigates whether cannabidiol (CBD) can reduce the adverse effects of neonatal procedural pain in rats, finding it decreases ultrasonic vocalizations but not long-term anxiety or neurodevelopmental outcomes.

Developmental switch in prediction and adaptation to pain in human neonates

This study investigates how term and preterm infants adapt to repeated noxious stimuli using EEG, finding that preterm infants lack the ability to update predictions for pain adaptation.

Inferring the infant pain experience: a translational fMRI-based signature approach

This paper translates adult fMRI pain signatures to infants, finding similar basic nociceptive encoding but differences in higher-level cognitive modulation of pain.