Lorenzo Fabrizi D

Postnatal development of somatosensory corticospinal projections in the mouse lumbar spinal cord

This study quantitatively analyzes the postnatal development of somatosensory corticospinal projections to the lumbar dorsal horn in mice, identifying three developmental phases.

Spontaneous activation of cortical somatosensory networks depresses their excitability in preterm human neonates

The paper investigates how spontaneous cortical activity in preterm infants reduces their excitability to external stimuli, revealing a refractory period mechanism.

Differential maturation of the brain networks required for the sensory, emotional and cognitive aspects of pain in human newborns

This study maps the postnatal development of brain networks for pain processing in infants, showing differential maturation of sensory, affective, and cognitive pain subnetworks.

Early life pain experience changes adult functional pain connectivity in the rat somatosensory and the medial prefrontal cortex

This study shows that early life pain exposure in rats increases functional connectivity in the somatosensory and medial prefrontal cortex, correlating with heightened pain hypersensitivity in adulthood.

Neurophysiological basis of hemodynamic responses in the developing human brain before the time of normal birth

This study investigates neurovascular coupling in preterm infants using EEG and fMRI, finding a relationship between EEG microstate duration and BOLD signal amplitude.

Widespread nociceptive maps in the human neonatal somatosensory cortex

The paper shows that newborn infants have widespread nociceptive maps in the somatosensory cortex, aligning with their disorganised pain behaviour.

Developmental switch in prediction and adaptation to pain in human neonates

This study investigates how term and preterm infants adapt to repeated noxious stimuli using EEG, finding that preterm infants lack the ability to update predictions for pain adaptation.