Integration of In Vitro and In Silico Approaches Enables Prediction of Drug-Induced Liver Injury
René Geci, Ahenk Zeynep Sayin, Stephan Schaller, Lars Kuepfer
Dividing Cmax by lowest in vitro toxicity potency separates drugs by liver-injury (DILI) risk, AUC up to 96%; PBK-predicted Cmax without clinical data reaches 91%.
Archives of Toxicology · Feb 17, 2026Peer-reviewedPharmacology & Toxicology✦ In-depth digest