Lars Kuepfer

High-throughput PBK modelling for dermal exposure: a pragmatic approach to predict systemic pharmacokinetics

This study uses high-throughput PBK modelling to predict systemic pharmacokinetics from dermal exposure using in silico data, achieving reasonable accuracy for key metrics.

Integration of In Vitro and In Silico Approaches Enables Prediction of Drug-Induced Liver Injury

Dividing Cmax by lowest in vitro toxicity potency separates drugs by liver-injury (DILI) risk, AUC up to 96%; PBK-predicted Cmax without clinical data reaches 91%.

A physiologically-based model of bile acid metabolism in humans

The paper develops a physiologically-based model of bile acid metabolism in humans to analyze how disease-related changes affect bile acid composition along the gut-liver-axis.

Potential Systemic Availability Classification of Chemicals for Safety Assessment

This paper develops a method to classify chemicals by Potential Systemic Availability (PSA) concern using physiologically based kinetic modeling and evaluates its alignment with expert judgment.

Computational identification of natural senotherapeutic compounds that mimic dasatinib based on gene expression data

The paper identifies natural compounds that mimic dasatinib's senotherapeutic effects using gene expression data, highlighting potential alternatives for senolytic therapy.

A physiologically based model of bile acid metabolism in mice

This study develops a physiologically-based model of bile acid metabolism in mice to understand its dynamics and implications for disease.

A physiology-based model of bile acid metabolism shows altered tissue concentrations after drug administration and in specific genotype subgroups

The paper develops a physiology-based model of bile acid metabolism to predict drug-induced liver injury risk and genetic susceptibility.