An emergent biosynthetic pathway to essential amino acids by metabolic metathesis
Julie Rivollier, Sandrine Gosling, Valérie Pezo, Marie‐Pierre Heck, Philippe Marlière
The paper demonstrates the use of alkene metathesis to generate essential amino acids in E. coli by catalyzing the conversion of APE to vinylglycine, which is then used to synthesize isoleucine and methionine.
ACS Omega · May 12, 2025Peer-reviewedSynthetic Biology