Author

Philippe Marlière

Institut de Biologie systémique et synthétiqueORCID 0000-0002-7869-5071Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Organism:E. coli· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Antoine DanchiniD· 1 shared Christos A. OuzounisiD· 1 shared Daxi WangiD· 1 shared Julie RivollieriD· 1 shared Junhua LiiD· 1 shared Marie‐Pierre HeckiD· 1 shared Sandrine Gosling· 1 shared Valérie PezoiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperGenomics

Antoine DanchinORCID

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2 papers

Recent·Most cited

An emergent biosynthetic pathway to essential amino acids by metabolic metathesis

Julie Rivollier, Sandrine Gosling, Valérie Pezo, Marie‐Pierre Heck, Philippe Marlière

The paper demonstrates the use of alkene metathesis to generate essential amino acids in E. coli by catalyzing the conversion of APE to vinylglycine, which is then used to synthesize isoleucine and methionine.

ACS Omega · May 12, 2025Peer-reviewedSynthetic Biology

A path towards SARS-CoV-2 attenuation: metabolic pressure on CTP synthesis rules the virus evolution

Zhihua Ou, Christos A. Ouzounis, Daxi Wang, Wanying Sun, Junhua Li, Weijun Chen, Philippe Marlière, Antoine Danchin

The paper identifies CTP synthesis as a metabolic bottleneck that constrains SARS-CoV-2 evolution towards attenuation and highlights viperin's role in antiviral defense.

Genome Biology and Evolution · Oct 28, 2020Peer-reviewedGenomics