Topic · Surgery · Medicine

Management of metastatic bone disease

OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.

3 papers

Palliative Irradiation Affects Temporal Degradation of Rodent Vertebral Bone Mechanics, Architecture, and Composition

Chenghua Wang, Madison Berardi, Samantha Martin, Christine Brown, Zahra Soltani, Mario Keko, Megan E. Rosa‐Caldwell, Marie Mortreux, Seward B. Rutkove, Stacyann Bailey, Ron Noah Alkalay

This study evaluates the longitudinal effects of high-dose irradiation on vertebral bone mechanics, architecture, and composition in rats, finding progressive deterioration in mechanical properties and trabecular structure.

bioRxiv · Jul 15, 2026 · PreprintBioengineering

3D-Printed Scaffolds for Local Chemotherapeutic Delivery in Resected Spine Metastases

Audrey A. Pitaru, Ateeque Siddique, Mansoureh Mohseni Garakani, Branda N Boakye, Michael H. Weber, Abdellah Ajji, Michael Robert Wertheimer, Isabelle Villemure, Lisbet Haglund, Derek Hadar Rosenzweig

This study evaluates 3D-printed composite scaffolds for local chemotherapy delivery in spinal metastases, showing effective drug release and bone integration in animal models.

bioRxiv · Jun 12, 2026 · PreprintBioengineering

Prediction of compressive strength of vertebral body with metastatic lesions based on quantitative computed tomography-based subject-specific finite element models

Rajdeep Ghosh, Eddie Shearman, Robert Roger, Marco Palanca, Enrico Dall’Ara, Damien Jerome Lacroix

This study develops and evaluates subject-specific finite element models based on quantitative CT to predict vertebral strength in metastatic lesions, showing no significant difference in failure load between metastatic and control vertebrae.

Bone · Jun 6, 2026Peer-reviewedBioengineering