Lisbet Haglund

Multiscale fracture resistance of human annulus fibrosus and its deterioration with degeneration

This study examines how degeneration affects the fracture resistance of human annulus fibrosus through mechanical testing and imaging, finding reduced toughness in degenerate tissue.

A Standardized In Vitro Platform for Senolytic Drug Discovery in Human Musculoskeletal Cells

This paper develops a standardized in vitro model for senolytic drug screening using human intervertebral disc cells and validates a metabolic activity assay as a scalable method to assess senolytic activity.

3D-Printed Scaffolds for Local Chemotherapeutic Delivery in Resected Spine Metastases

This study evaluates 3D-printed composite scaffolds for local chemotherapy delivery in spinal metastases, showing effective drug release and bone integration in animal models.

Targeting therapy-induced senescence across multiple breast cancer subtypes in a metastatic bone-like microenvironment

This study shows that combining chemotherapeutic drugs with senolytics reduces senescent cells and tumor growth in breast cancer models.

A novel method to sort and enrich sensory neurons

This study identifies surface markers for isolating sensory neurons and develops a FACS panel for their enrichment without transgenic mice, validated by microscopy and scRNA-seq.

Targeting breast cancer senescence in 3D models of bone metastasis

This study shows that combining Doxorubicin with senolytics reduces senescence and tumor growth in 3D models of bone metastasis.

Beyond miRNA cargo profiles: anti-inflammatory roles of extracellular vesicle-enriched miRNAs derived from human intervertebral disc cells unveiled by functional testing

The paper identifies anti-inflammatory miRNAs in extracellular vesicles from human intervertebral disc cells and shows their synergistic effects in reducing inflammation and promoting regeneration.

Tissue-to-Analysis Framework Enables Multiscale Mapping of the Architectural and Cellular Organization in the Human Dorsal Root Ganglion

The paper develops a tissue-to-analysis framework to map the cellular and architectural organization of human dorsal root ganglia using transcriptomic and protein data.

Neutrophil-neuronal crosstalk drives arthritis-induced pain

This study identifies SEMA4D and OSM as mediators of neutrophil-neuron communication in arthritis-induced pain, showing their role in neuronal sprouting and hypersensitivity.

Senolytic Therapy as a Preventive Strategy for Low Back Pain

This study shows that early senolytic treatment prevents low back pain in mice by reducing senescence markers and inflammation in spinal tissues.

Therapeutic effects of PDGF-AB/BB against cellular senescence in human intervertebral disc

This study shows that PDGF-AB/BB treatment reduces senescence in human intervertebral disc cells by modulating gene expression related to cell cycle, metabolism, and oxidative stress.

Fibromyalgia patients with high levels of anti-satellite glia cell IgG antibodies present with more severe symptoms

This study finds that fibromyalgia patients with higher anti-satellite glia cell IgG antibodies have more severe symptoms, suggesting these antibodies may contribute to disease severity.

DIPPER: a spatiotemporal proteomics atlas of human intervertebral discs for exploring ageing and degeneration dynamics

DIPPER provides a spatiotemporal proteomics atlas of human intervertebral discs, revealing region-specific regulatory profiles and a hydration matrisome linked to MRI intensity.

Single-cell RNA sequencing reveals time- and sex-specific responses of spinal cord microglia to peripheral nerve injury and links ApoE to neuropathic pain

This study uses single-cell RNA sequencing to analyze spinal cord microglia responses to nerve injury, identifying sex- and time-specific changes and a role for ApoE in neuropathic pain.