De novo Design of a Vanadium Haloperoxidase
Ryan A. Herold, Lancia A. Carson, Kevin J. Anderton, Kent J. Griffith, F. Akif Tezcan
This paper designs a de novo vanadium haloperoxidase (VAN1) that binds vanadate and catalyzes bromination of aromatic substrates, validated by structural and functional experiments.
bioRxiv · Oct 19, 2026 · PreprintBiochemistry