Author

F. Akif Tezcan

University of California San DiegoORCID 0000-0002-4733-6500Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 1 Approach:machine learning (classical)· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein design· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

B. D. CookiD· 1 shared Kelly L. McGuireiD· 1 shared Kent J. GriffithiD· 1 shared Kevin J. AndertoniD· 1 shared Lancia A. CarsoniD· 1 shared Mark A. HerzikiD· 1 shared Ryan A. HeroldiD· 1 shared Sarah M. NarehoodiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 16 mutual co-author links

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1 shared paperBiophysics

B. D. CookORCID

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2 papers

Recent·Most cited

De novo Design of a Vanadium Haloperoxidase

Ryan A. Herold, Lancia A. Carson, Kevin J. Anderton, Kent J. Griffith, F. Akif Tezcan

This paper designs a de novo vanadium haloperoxidase (VAN1) that binds vanadate and catalyzes bromination of aromatic substrates, validated by structural and functional experiments.

bioRxiv · Oct 19, 2026 · PreprintBiochemistry

Preparation of oxygen-sensitive proteins for high-resolution cryoEM structure determination using (an)aerobic blot-free vitrification

B. D. Cook, Sarah M. Narehood, Kelly L. McGuire, Yizhou Li, F. Akif Tezcan, Mark A. Herzik

This paper presents a streamlined method for (an)aerobic vitrification of oxygen-sensitive proteins using an automated device, enabling high-resolution cryoEM structure determination.

Nature Communications · Apr 14, 2025Peer-reviewedBiophysics