TMT-based quantitative proteomic assessment of Vicia sativa induced neurotoxicity by β-cyano-L-alanine and γ-glutamyl-β-cyano-L-alanine in SH-SY5Y cells.
Samuel Riley, Vy Nguyen, Rudrarup Bhattacharjee, Pei Qin Ng, Tarin Ritchie, Karthik Shantharam Kamath, Ian Denis Fisk, Jozef Gécz, Raman Kumar, Iain Robert Searle
This study uses TMT-based proteomics to analyze the effects of BCA and GBCA on SH-SY5Y cells, identifying distinct dysregulated proteins and pathways associated with neurotoxicity.
Scientific Reports · Dec 11, 2025Peer-reviewedPharmacology & Toxicology