Systematic multivariate analysis of chromatin complex dependencies reveals Set1C/COMPASS as a melanoma-enriched epigenetic vulnerability
Luisa Quesada Camacho, Mohammad Fallahi‐Sichani
Complex-level DepMap dependency modeling across 42 cancer types nominates Set1C/COMPASS as melanoma-enriched; CXXC1 knockdown lowers H3K4me3, curbs proliferation, and suppresses MYC/E2F programs in responsive melanoma lines.
PLoS Computational Biology · Aug 27, 2026Peer-reviewedCancer Biology✦ In-depth digest