Chromatin Remodeling and Cancer

The BAF chromatin remodeling subunit ARID1B coordinates cell-cycle exit and motor neuron differentiation

This study shows ARID1B is essential for transitioning from cell-cycle progression to motor neuron differentiation in mouse embryonic stem cells.

Temporal Dynamics of SMARCA4 Loss Define Its Role in Myogenic Differentiation of Alveolar Rhabdomyosarcoma

This study shows that acute SMARCA4 loss in ARMS cells does not induce differentiation or alter proliferation, contrasting with long-term knockdown effects.

Coordinated alterations in SWI/SNF chromatin remodeling complex, mRNA splicing and mRNA methylation as hallmarks of salivary gland adenoid cystic carcinoma (SACC)

This study identifies coordinated disruptions in chromatin remodeling, RNA methylation, and splicing as key features of salivary gland adenoid cystic carcinoma.

Mechanistic insights into chromatin modulation by the orphan remodeler ATRX

This study reveals how ATRX modulates chromatin by unwrapping nucleosomal DNA through a unique 'pin-like' structure and other features, proposing a 'climbing' mechanism for DNA translocation.

ARID2 loss destabilizes PBAF and drives colorectal cancer

This study shows ARID2 loss destabilizes the PBAF complex, leading to CRC progression through disrupted chromatin remodeling and pathway perturbations.

Interplay of NuA4/TIP60 and PRC2 Complex Activities in Fusion Driven Endometrial Stromal Sarcoma

This study investigates the MBTD1-EZHIP fusion protein in LGESS, showing it forms a TIP60-PRC2 complex, reduces H3K27me3, and upregulates oncogenes, similar to JAZF1-SUZ12 but with distinct mechanisms.

E3 ubiquitin ligase WWP2 regulates stability and tumor suppressive properties of the chromatin remodeler ARID1B

This study identifies WWP2 as an E3 ubiquitin ligase that regulates ARID1B protein stability and tumor suppressive function through ubiquitination.

Rewiring of Integrin Signaling and Cell-cycle Deregulation Drive SMARCB1-Deficient Epithelioid Sarcoma

This study identifies integrin signaling and cell-cycle deregulation as key drivers of SMARCB1-deficient epithelioid sarcoma and highlights therapeutic targets.

Systematic multivariate analysis of chromatin complex dependencies reveals Set1C/COMPASS as a melanoma-enriched epigenetic vulnerability

Complex-level DepMap dependency modeling across 42 cancer types nominates Set1C/COMPASS as melanoma-enriched; CXXC1 knockdown lowers H3K4me3, curbs proliferation, and suppresses MYC/E2F programs in responsive melanoma lines.

BAF perturbation heightens cancer cell dependence on CDK12-driven transcription elongation by RNA polymerase II

The paper identifies a co-dependency between CDK12 and the BAF chromatin-remodeling complex in TNBC, showing that their co-inhibition synergistically reduces cancer cell viability.

Targeting SAGA/ATAC complexes disrupts chromatin regulation and cholesterol metabolism in diffuse midline glioma

This study shows that targeting SAGA/ATAC complexes disrupts chromatin regulation and cholesterol metabolism in diffuse midline glioma, leading to reduced tumor growth.

Urothelial-lineage master transcription factor hub proteomics shows mechanisms impeding urothelial cancer cell differentiation

The paper identifies CoA and CoR dysregulation in urothelial cancer cells and shows that CoR inhibition can restore differentiation.

Defective Microhomology-Mediated End-joining in SMARCB1-Deficient Tumors

This study identifies a defect in MMEJ repair in SMARCB1-deficient tumors, leading to hyper-dependence on the FA/BRCA pathway, which can be targeted for therapy.

SWI/SNF Alterations Define a Chromatin-Dependent Subtype of Urothelial Carcinoma

This paper identifies a chromatin-altered subtype of urothelial carcinoma defined by SWI/SNF alterations, showing it is sensitive to HDAC inhibition and immunotherapy.

Histone deacetylase activity limits the response to EZH2 inhibition-based therapy in epithelioid sarcoma and is targetable by epigenetic combination

This paper identifies HDAC inhibition as a strategy to overcome resistance to EZH2 inhibitors in INI1-deficient epithelioid sarcoma by restoring H3K27 acetylation and enhancing therapeutic response.

PBRM1-Dependent PBAF Targeting is Required for EMT and Metastasis in Breast Cancer

This study shows that PBRM1 in PBAF is essential for EMT and metastasis in breast cancer by enabling promoter targeting and DNA accessibility for TGFβ1-inducible genes.

The CoREST complex inhibitor, corin, leads to decreased tumor growth, increased cellular differentiation and extended lifespan in atypical teratoid rhabdoid tumor xenograft models

This study shows that corin, a CoREST inhibitor, reduces ATRT tumor growth, increases differentiation, and extends lifespan in xenograft models.

Loss of cBAF Complex Confers Sorafenib Resistance in Liver Cancer

This study identifies the cBAF complex as a driver of sorafenib resistance in liver cancer by disrupting hepatocyte lineage identity and promoting a mesenchymal drug-tolerant state.

ARID1A orchestrates the activity of FOXA1 and AP-2 transcription factors in lobular breast cancer cells

This study identifies ARID1A's role in regulating FOXA1 and AP-2 transcription factors in lobular breast cancer, revealing a distinct regulatory network and potential implications for metastasis.

MLL3 adaptor function, not methyltransferase catalytic activity, is essential for breast tumor suppression

This study shows that MLL3's tumor suppressor role in breast cancer depends on its adaptor function, not its catalytic activity.

Differential DNA damage response to WRN inhibition identifies a targetable vulnerability in ARID1A-mutated cancers

This study identifies WRN as a therapeutic target in ARID1A-mutated cancers, showing that its inhibition causes DNA damage and cell death, with potential for combination therapy with p21 inhibition.

Globular domain histone H3R131C mutation remodels chromatin accessibility to promote oncogenic transcriptional programs

Elongin B orchestrates chromatin and transcriptional programs in H3K27M-mutant diffuse midline glioma

This study identifies elongin B as a key regulator of Pol2 elongation in H3K27M-mutant diffuse midline glioma, showing its role in maintaining chromatin and transcriptional dysregulation.

Two distinct SWI/SNF complexes direct chromatin-linked transcriptional programs in Toxoplasma

The paper identifies two distinct SWI/SNF complexes in Toxoplasma gondii that have different roles in transcriptional regulation during the cell cycle and development.

ISWI remodeler facilitates cBAF genomic binding to drive cell fate transition

This study shows ISWI remodelers are essential for muscle and adipose development and link LDTF binding to cBAF recruitment during cell fate transition.

Mutual Antagonism Between PRC1 Condensates and SWI/SNF in Chromatin Regulation

The paper shows PRC1 condensates exclude SWI/SNF from chromatin, and SWI/SNF-bound chromatin reduces PRC1 binding, indicating mutual antagonism between these complexes.

ARID1A deficiency unleashes centromeric RNA transcription to drive chromosomal instability and boosts PKMYT1 inhibitor efficacy via RNA sensing

This study shows that ARID1A deficiency increases centromeric RNA transcription, causing chromosomal instability and enhancing the effectiveness of PKMYT1 inhibitors through RNA sensing.

Nucleolar Condensation Orchestrates rRNA-dependent Mobility and Spatiotemporally Enriches rDNA-binding of Human Chromatin Remodeler BRG1

This study shows that BRG1 forms nucleolar condensates that regulate rDNA binding and rRNA-dependent mobility, linking chromatin remodeling to nucleolar architecture.

Leveraging the BAF chromatin remodeling complex for targeted transcriptional rewiring in cancer

This paper introduces TRIPs, neomorphic molecules that recruit BAF complexes to rewire BCL6 in DLBCL, inducing apoptosis through chromatin remodeling.

BAF complexes maintain accessibility at stimulus-responsive chromatin and are required for transcriptional stimulus responses

The paper identifies BAF-dependent chromatin regulatory elements and shows that BAF complexes are required for transcriptional responses to stimuli.