The anxiolytic-like effect of the aqueous extract of Punica granatum depends on the stress level of fish and mice: Evidence of a homeostatic re-establishing effect
Adelis Pantoja, Jessica M. Chan-Monroy, Marissol M Leite, Nancy Cervantes-Anaya, Nelly Maritza Vega‐Rivera, Thaeny Regina Ribeiro Rodrigues, Adriano Oliveira Silva Meneses, Bruna Patrícia Dutra Costa, Diógenes Henrique de Siqueira‐Silva, Mônica Gomes Lima, Erika Monserrat Estrada-Camarena, Caio Maximino
This study evaluates the anxiolytic-like effects of Pomegranate extract on fish and mice under stress, finding it blocks stress-induced anxiety and depression-like behaviors.
bioRxiv · Oct 15, 2026 · PreprintPharmacology & Toxicology