Adriaan W. Bruijnzeel

This study shows chronic fentanyl reduces anxiety-like behavior in opioid-dependent rats, with sex-specific effects, suggesting potential for misuse due to anxiolytic effects.

This study examines sex differences in anxiety-like behavior in male and female mice using open field and elevated plus maze tests, finding convergent activity measures but divergent anxiety dimensions.

This study identifies bioactive kavalactones in AB-free kava that suppress lung inflammation via PKA/CREB/COX-2 signaling, offering a new therapeutic approach for smoke-induced pulmonary diseases.

This study shows AB-free kava reduces anxiety-like behavior in mice without sedation but does not prevent nicotine-induced suppression of exploration.

This study shows chronic nicotine increases impulsive action in rats, and nAChR antagonism reduces nicotine-related impulsivity, while agonism does not.

This study shows that CBD reduces oxycodone self-administration in rats with neuropathic pain without diminishing oxycodone's pain-relieving effects.

This study shows AB-free kava reduces tobacco smoke-induced CREB phosphorylation in mouse cerebellum, suggesting a potential therapeutic role.

This study shows that intermittent long-access nicotine self-administration in rats leads to persistent anhedonia, with reward thresholds increasing during both spontaneous and precipitated withdrawal.

This study evaluates AB-free kava's effects on tobacco smoke-exposed mice, showing it mitigates health deficits with safety, suggesting potential for reducing tobacco-related harm.

This study investigates how nicotine's rewarding effects in rats are influenced by glucocorticoid and nicotinic acetylcholine receptors using the ICSS procedure.

This study examines age-related changes in affective behaviors and functional connectivity in mice, finding differences in behavior, connectivity, and metabolome across age groups.