Gut Bacteria Encode Reductases that Biotransform Steroid Hormones
Gabriela Arp, Angela K Jiang, Keith Dufault‐Thompson, Sophia Levy, Aoshu Zhong, Jyotsna Talreja Wassan, Maggie R. Grant, Yue Li, Brantley Hall, Xiaofang Jiang
Gut bacteria encode 5β-reductase, fused 3β-HSDH/Δ5-4 isomerase and Δ6-3-ketosteroid reductase enzymes acting on steroid hormones; two of these genes are enriched in female gut metagenomes.
Nature Communications · Jul 8, 2025Peer-reviewedMicrobiology✦ In-depth digest