Discover, rate, and discuss biology preprints.

The paper shows ESAT-6 and CFP-10 limit cGAS-STING activation by degrading DNA and restricting Zn2+ availability during mycobacterial infection.

This study shows that magnetic fields affect flavin autofluorescence in E. coli, with the effect depending on metabolic state and suppressed by carbon sources.

This study shows scalp EEG can detect motor sequence replay during wakeful rest, with accelerated memory reactivation enhancing learning and replay strength.

The paper investigates cerebello-basal ganglia network connectivity across adulthood and aging, finding age-related changes, sex differences, and associations with cognitive performance and steroid hormones.

This study shows ARID1B is essential for transitioning from cell-cycle progression to motor neuron differentiation in mouse embryonic stem cells.

This study identifies DUR-1, a secreted LEA-like protein in C. elegans, as a basement membrane component that enhances tissue integrity and stress survival.

The paper systematically maps the localization of 49 actin-binding proteins during C. elegans gastrulation to understand their roles in apical constriction.

The paper identifies a critical mechanical time window during late embryogenesis for proper proprioceptor development in flies.

The paper designs and computationally evaluates a CRISPR base editing strategy to correct the ASPA variant associated with Canavan disease, identifying a candidate sgRNA with favorable editing characteristics and genome-wide specificity.

This study fine-tunes an intracellular allosteric pocket of NTSR1 to program GPCR signaling bias, revealing how ligand modifications alter transducer coupling and downstream signaling.

The paper identifies and characterizes U6 promoters in Ulva prolifera, showing their dual transcriptional activity and utility for CRISPR-Cas9 genome editing.

This study identifies TFP5 as a transporter critical for lipid homeostasis in apical secretory organelles of Toxoplasma gondii, impacting parasite virulence.

This study evaluates how resolution choices affect lidar-derived forest structural complexity metrics and their ecological interpretations in conservation management.

The paper investigates how PRPS1 disease alleles affect polymerization and cytoskeletal organization in yeast and human cells, linking these changes to metabolic state and phenotypic overlap.

This paper optimizes the ORBIT protocol for efficient gene deletion in Mycobacterium abscessus, enabling precise genetic manipulation for studying its physiology and pathogenesis.

This study identifies aspirin's molecular effects on preeclamptic placenta by analyzing gene expression in different placental regions, showing downregulation of inflammatory and metabolic pathways.

This study shows that grooming movements in rhesus macaques are adapted from feeding movements, with similar hand motions used for both tasks.

This study shows that CBX3 deletion increases ROS and lipid ROS levels in CRC cells, sensitizing them to ferroptosis by disrupting the IFNγ/SLC7A11/SLC3A2 axis.

This paper introduces synthetic polymer-based lipid alternatives for lipid nanoparticles, showing they can replace standard lipids while maintaining transfection activity.

This study shows that menopause hormone treatment (E2) reduces atherosclerosis in young mice but not older mice, due to age-related changes in inflammation and estrogen receptor signaling.