Oscar Vadas

This study identifies TFP5 as a transporter critical for lipid homeostasis in apical secretory organelles of Toxoplasma gondii, impacting parasite virulence.

The paper identifies a nucleolar module involving Fap7 that ensures proper uS11 modification and incorporation into pre-ribosomes, safeguarding ribosome biogenesis.

The paper identifies a Type II RhlB helicase in Pseudomonas aeruginosa that forms toxic condensates, which are resolved by RNase E through antagonizing phase separation.

This study provides the structural model of the Bcl-xL/tBid complex at the mitochondrial membrane, revealing its dynamic architecture and mechanism of indirect apoptosis inhibition.

The paper determines cryo-EM structures of MEK1 activating ERK2, elucidating specificity and activation mechanisms in the MAPK pathway.

The paper shows MyoL is essential for anchoring preconoidal rings to the conoid in Toxoplasma gondii, supporting motility and invasion.

This study identifies RNG2 as a critical protein tethering the conoid to the apical polar ring in Toxoplasma gondii, essential for parasite motility and invasion.

This study identifies a GAF signaling domain that regulates PPIP5K phosphatase activity in phosphate homeostasis through structural and functional analyses.

The paper shows soluble β-tubulins sequester TTC5 to regulate tubulin mRNA decay, with loss of sequestration leading to reduced mRNA levels and chromosome segregation defects.

The paper investigates how the SUV39 SET domain mediates crosstalk between H3K9 methylation and H3K14 ubiquitination in heterochromatin formation.